It was about two in the morning and everyone has went to...

It was about two in the morning and everyone has went to bed. I was awake, the house was so quite, I could hear everyone breathing. Elena and Andrea where sleeping on my bed with me. I was sitting at the foot of my bed watching Elena and Andrea sleep. It felt as if I was still going to cry even hours after everything. Wondering if they were going to show this part on T.V. or leave it out. Wondering if they were even going to keep the show going after this. Thinking I heard a door open, my heart speed up. What if... a scream almost left my lips when I see Zayn poke his head around the door looking in. He just looks at me, then holding out his hand for me to come. Slowly, I get up, taking him hand, letting him lead me. He walks us to the†¦show more content†¦He glared at her. I did my best to act like nothing was wrong or going on; that was the truth. â€Å"Do you mind?† I said to Louis who was standing right in front of me. He stepped to the side, so I could stand up. â€Å"Thank you.† I said, looking at Zany, he smiled. Starting to walked off I heard Andrea say â€Å"Wait of me.† I looked back, Zayn was running his hand throughout his hair, rubbing his eyes. â€Å"So?† Andrea said, smiling at me. Walking into our room I could feel her watching me. â€Å"Where have you to been?† Elena said, then adding, â€Å"Where are you dress and Zoey isnt?† Andrea looked around the room. â€Å"Is it just us?† she whisper. Elena shock her head no. I took this chance to sneak out of the room. Louis and Zayn were right where we left them. Right before I opened the glass door I could see my refection, I was in my pjs tank top and shorts, my hair as a bit messy; not really caring I open the door. Walked out. Walking off I toss my hair up in a ponytail. Do a few quick stretches. Then take off running. I havent been running in weeks. Part way down the beach I can hear my name being called so I stop running. Elena and Andrea where walking, seeing Elena cant run. Waiting for them to get closer I sit. I couldnt see the house any more. Once they got to me they just look at me, sitting down. I just look at them back. â€Å"Did she tell you?† I asked. The sun was shining, the wind was softly blowing as the two girl nod their headsShow MoreRelatedMitochondrial Pathway Of Mitochondrial And Mitochondrial Permeability Transition977 Words   |  4 Pagesdefined by the presence of conserved Bcl-2 homology domains (BH1 to BH4). Up to 30 Bcl-2 family genes have been identified in mammals, which have either pro-apoptotic or anti-apoptotic functions. Some of the anti-apoptotic members include Bcl-2 itself, Bcl-XL, Bcl-w, BAG and Mcl-1 which possess all domains of BH1 to BH4. The pro-apoptotic family proteins can be divided into two subgroups: consists of Bak, Bax, and Bok with possess BH1 to BH3 domains, and Bad, Bid, Bik, BNIP3, Bim, Bmf, Blk, Hrk,Read MoreBcl-2 Protein Essay790 Words   |  4 Pagespro-apoptic proteins BAK and BAX, which undergo oligomerization that lead to outer mitochondrial membrane (OMM) permeabilization and cytochrome c release. This, in turn, triggers caspase activation and promotes cell death (6, 7). This inhibi tion occurs by BH1-BH3 domains of Bcl-2, which they form a hydrophobic pocket binding and inhibiting BH3- only protein (Bim), consequently preventing the activation of BAK and BAX (8). Second, BCL-2 targets the inositol 1, 4, 5-trisphosphate receptor (IP3R) through itsRead MoreDevelopment Of BL 2 And BCL XL Case Study1393 Words   |  6 Pagesdevelopment of haematological cancers. The family includes pro-apoptotic members (which promote cell death) and anti-apoptotic or pro-survival members (which prevent cell death) which are then categorised based on the number of BCL-2 homology domains (BH1, BH2, BH3, BH4) they share4, (for example the anti-apoptotic proteins BCL-2 and BCL-XL share very similar BH3 domains). They all share a similar general fold consisting of two central hydrophobic ÃŽ ±-helices surrounded by six or seven amphipathic ÃŽ ±-helices4